News!New progress in the field of science and technology in Nan University in July

Author:Nanjing University Time:2022.08.03

July Science and Technology News

Potential treatment targets of liver fibrosis

Liver fibrosis is the pathological process of chronic liver disease to develop liver cirrhosis and liver cancer. The main pathological injury of blood -absorbing disease is liver fibrosis. As of the end of 2019, there are still more than 30,000 patients with advanced hemorrhage. However, there are no fundamental anti -fibrosis drugs clinically, and the mechanism of liver fibrosis has not been fully clarified. Recently, Professor Hua Chun, the School of Life Sciences of Nanjing University, conducted a study with the Institute of Prevention and Treatment of the Jiangsu Hematology and Worms. It was found that RIP3 lacks liver fibrosis that can alleviate the induction of Japanese blood absorption. RIP3-JNK-CJUN/EGR1 shaft feedback regulates the generation of inflammatory factor and ROS, thereby activating HSC and promoting blood-absorbing liver fibrosis. Inhibit JNK to prevent blood absorption and liver fibrosis. Therefore, RIP3 and its signal pathway may be a new drug target for pathogenic liver fibrosis. The study further clarified the molecular mechanism for the formation of liver fibrosis, providing new ideas for the research and development of drugs of liver fibrosis.

The molecular mechanism and signal pathway diagram of RIP3 in the liver fibrosis of the blood suction disease

The tenth anniversary of commemorating Higgs particle discovery -the ATLAS team of Nanjing University has made important contributions in the research results of the Higgs particles in the large -scale strong collision.

Recently, the European Nuclear Research Center (CERN) large -scale strong -dongzer LHC ATLAS and CMS experiments on the "Nature" magazine for the first time released the joint measurement results based on all RUN2 data. The most accurate measurement result of the particle nature. The ATLAS group in Nanjing University has made important contributions to the study. Since joining the ATLAS international cooperation group in 1998, the ATLAS group of Nanjing University has actively participated in the construction of the ATLAS experiment and its upgrade and physical analysis. Professor Jinshan of Nanjing University School of Physics presided over the "ATLAS Experiment RUN2 Data Physics Analysis" of the Ministry of Science and Technology's key R & D project. The ATLAS group in Nanjing University has made long -term important contributions in the discovery of Higgs particles and the bottom quark. The coupling of particles and Tao Qingzi also made key contributions in the measurement measurement, and served as the person in charge of the analysis. The above discovery of the coupling results of Higgs and Datak and Tao Qingzi were recommended by the Ministry of Science and Technology as major scientific and technological achievements of key R & D plans for the 13th Five -Year Plan. In addition, the ATLAS group of Nanjing University has made important contributions in the study of Higgs particle decline to the precise measurement of the end of the twins and the study of Higgs particles auto -coupled measurement.

Reveal flexible silicon -based nanoparticles to enhance anti -tumor immune efficacy

Anti -tumor immunotherapy based on dendritic cells (DC) can be used as an immune tumor tumor antigen by nanoparticles as an immune tumor. On this basis, Professor Mu Yongbin's team affiliated to the Academy of Medical College of Nanjing University cooperated with Professor Teng Zhaogang of Nanjing University of Posts and Telecommunications to prepare a flexible medium organic silicon -based nano -vaccine (SmonV) and studied the mechanical performance of the nano vaccine. Impact and related mechanisms of immune response. Studies have found that SMONV can promote more intakes of DC confrontation because of its flexibility, and induces a large amount of antigen's cytoplasm delivery through the internal body escape, causing DC to be effective maturity and antigen cross -propynce. In addition, the soft characteristics make SMONV improve the lymphatic drainage efficiency of the body's antigen and activate high -efficiency body fluid and cellular immunity. The result of the vaccination of the nanoma vaccination of the rumor tumor further shows that the subcutaneous injection of SMONV can efficiently induce antigenic special alienation CD8+ T cell immune response, improve the immunosuppressive suppression of regulatory T cells, enhance the immune memory of memory T cells, effectively suppress the effects Tumor growth of rumor tumor mice. In addition, SMON and anti-PD-L1 antibody combined applications can further enhance its antitumor effect. This work proves that the mechanical properties of nanoparticles play an important role in DC -mediated anti -tumor immunity, and provide a reference for future mechanical performance design of anti -tumor vaccines.

SMONV effectively activate DC mediated anti -tumor immune response

Early evolutionary research on vertebrates has achieved important progress

Recently, Professor Jiang Baoyu, the research group of Professor Jiang Baoyu of the School of Earth Sciences and Engineering of Nanjing University and the research team of "Early Early Evolution of Life System" led by Researcher Zhu Maoyan, the Institute of Geological Paraphority of the Chinese Academy of Sciences, confirmed that my country 518 million years ago Chengjiang The Yunnan worm in the animal group is the most primitive group of vertebrates. The result was published in the journal "Science". SCIENCE News Center (Scipak) promoted the paper as a highlight article. The Burgis shale animal group, Canada, which is about 505 million years old and the Chengjiang Animal Group in Chengjiang, Yunnan, China, which is about 518 million years ago, has a rich, exquisitely preserved animal fossil characterized by soft body structure. The mysteries of vertebrates and early evolution provide precious materials. The research team discovered the stacked disk -shaped cell structure (Stacked Discoid Structure) and the Fibrillin Microfibril in the Stacked Discoid Structure. It belongs to the original vertebrate. In addition, research also proves that Yunnan worms are in the most foundation of the vertebrate spectrum, between tails and other vertebrates (including existing and fossil species). Yunnan worm provides key evidence for revealing the origin and early evolution of vertebrates, and the exploration of the evolution of vertebrate jaw and other key characteristics will have a profound impact. Structure potential. Yunnan worm ecological restoration map

Global vegetation growth has made important progress in the urban environmental response

The impact of quantitative urban environment on the growth of vegetation and its driving mechanism on the global scale will help better understand the response to the changes in the global environment. Professor Yang Lin, Professor Yang Lin of Nanjing University, research team of Academician Zhou Chenghu, and doctoral student Zhang Lei, including a large amount of satellite remote sensing big data based on the nearly two decades (2001-2018). Progress on the direct and indirect effects of vegetation growth. Faced with the major challenges brought by climate change and population growth today, the research team deeply explored the role of vegetation growth and enhancement mechanism caused by the changes in urban environment led by human activities, and enriched the existing research on the environment for the environment for the environment. How to affect the understanding of vegetation growth on the global and local standards, and provides many inspirations to the adaptive changes that plants may produce in the context of future climate change through the "natural laboratory" of the urban environment. Climate change provides reference and support.

Time and space pattern of urbanization on the indirect impact of global vegetation growth. A, B: indirectly impact the many years of the annual average size and its changes in the latitude; E, f: indirectly affect the changes in the climate background conditions where the city is located

New mechanism of liver insulin action

Insulin has a vital role in controlling energy metabolism. After meals, insulin is secreted in large quantities to the blood to promote the absorption of glucose, fatty acids, and amino acids to regulate the stability of the whole body. Chen Shuai and Wang Hongyu's team of Nanjing University Medical College separated the phosphoric acid -controlled target protein regulated by insulin in the liver of mice through phosphate -based protein groups, which identified a new insulin response protein Trim24 (also known as TIF1ɑ). TRIM24 is an e3 pan -connecting enzyme of a TRIM family, which mainly exists in the nucleus and regulate gene transcription in the basic state. Insulin stimulation can significantly transfer Trim24 to cytoplasm to form a dot structure. The protein kinase PKB phosphate TRIM24 carbon terminal, 1043 thrill acids located in its second nuclear positioning sequence, this phosphorylation event can promote the help of Trim24 from the help of nuclear output protein XPO1 from the nucleus to the cytoplasm. TRIM24 can generalized EDC4 to reduce the latter's interaction with the hat enzyme component DCP1, which affects the formation of a removing enzyme complex. After experimental analysis, Trim24 is a new insulin response protein. Insulin stimulation can transfer it from the nucleus to the cytoplasm, regulate the P-BODY function, and then regulate the mRNA stability of PPARγ, thereby regulating liver lipid metabolism. This new insulin action mechanism can provide new potential drug research and development targets for the treatment of fatty liver.

TRIM24 response to the pattern diagram of the P-BODY function regulating P-BODY function

Domestic diffraction of horizontal orbit angle motion beam

Recently, Professor Lu Yanqing, the School of Modern Engineering and Applied Sciences of Nanjing University, realized the production of super high -end space -time Bessel vortex light beams (L = 100), which has strictly equivalent mathematics. The law of transmission evolution, which in which theoretically proposes the use of color dispersion projects to achieve a horizontal rail angular beam that is not diffused without time. Based on the reverse design of the Fourier transformation of the space, the researchers proposed a instant X -ω modulation method that realizes a specific space -time spectrum, which successfully generated the time and space Bessel vortex with a maximum topology of 100. Further research not only provides direct evidence of photons that can have ultra -high horizontal OAM, but also proposes a general strategy to generate this OAM. For the first time, the research team observed the pure time diffraction effect on the horizontal OAM beam, and proved that it can be dispersed through the internal color dispersing the time symmetrical evolution of the time generated, and also proposed that the color scattered project is used to achieve the horizontal rail angular beam that is not diffused without time. The above results paved the way for further research and application of horizontal OAM beams. Top Lotus L is the experiment and simulation results of the Time and Space Trives of 10, 25, 50, and 100

IEEE Integrated Circuit Field Flagship Conference won the best thesis award at the flagship conference

From July 4th to 6th, 2022, the IEEE Computer Society's oversized integrated circuit annual seminar was held in Pavos, Cyprus. The paper of Professor Wang Zhongfeng, the School of Electronic Sciences and Engineering of Nanjing University, "An Efficient Accelerator of Deformable 3D Convolutional Network for Video Super-Resolution" (author: Zhang Siyu, Mao Wendong, Wang Zhongfeng), won the "Best Thesis Award" issued by the conference. This is the second time that Professor Wang has won the best thesis award for the annual conference. It is also the team's fifth time in the international academic conference in the IEEE integrated circuit related fields in the past three years. This time, Professor Wang's award -winning papers designed a decoupled calculation strategy, multi -dimensional cross -storage solution, and special hardware architecture for the deformation 3D convolution network, which greatly improved the calculation efficiency and completely solved the operator belt. Come to visit conflict. The experimental results show that the design proposed by the article can significantly improve the video super -resolution reconstruction effect of the existing solution and improve the processing speed.

Draw the reference map

Non-Human Primate (Non-Human Primate) shows similar characteristics to humans in many aspects such as genetic, organ structure, physiological function, pathological reactions, and biochemical metabolism. It is an ideal animal model for biomedical research and drug development. Important research value. Chen Dijun, and Sun Yang team of the National Key Laboratory of the National School of Life Sciences of Nanjing University and the National Key Laboratory of the National Key Laboratory of Medicine and Biotechnology, Xie Yicheng Team of the Children's Hospital Affiliated to Zhejiang University Medical College, 16 organs (heart, liver, spleen, lungs, kidney, stomach Data from colon, muscles, trachea, aorta, fat, bladder, tongue, breast, uterus, and testicles) for single-cell transcription group sequencing (SCRNA-seq) and single-cell chromatin open texture (scatac-seq), To build a single -cell multi -group reference map of the multi -cell cells of crab and monkeys. Based on this single -cell map, the research team found that crab monkeys and people have rich types of immune cells and epithelial cells, and have high cell composition and cell interaction in the corresponding organs, as well as the correlation between gene expression patterns Essence These results suggest that crab monkeys are an ideal model for studying complex diseases. Related results can provide a guiding basis for scientists to choose the appropriate animal model.

Crab Monkey Monkey Multi-organ single-cell multi-group multi-group reference map construction and analysis (A) experimental design; (B-C) cell type identification; (D-E) two groups of component data integration and consistency analysis

Comprehensive Analysis Platform of Botanical Regulation Group Chip-hub

Plant genome regulation regions are rich in a large number of agronomic traits and crop domestication associations. A targeted editing regulatory components can accurately change the expression of important agricultural traits genes. Establishing the reference map of plant regulatory genome will provide important resources for the precise improvement of crops. Chen Dijun's research group of the School of Life Sciences of Nanjing University collected more than 40 species, with a total amount of more than 10,000 sets of plant regulatory group data. It adopts data analysis standards recommended by the ENCODE plan. Processing, the quality of the data system, and integrating the data and analysis results into the online database of Chip-hub (https://biobigdata.nju.edu.cn/chiphub/). The study can not only help plant scientific scholars to quickly locate potential regulation elements on plant genomes, but also provide convenient information retrieval and data analysis visualization platforms, providing valuable reference resources for the precise improvement of crops.

A-D. Overview of the data collected by the plant regulation group; e. The data analysis process diagram of the data analysis process

Multi -channel conversion and distribution based on the medium hyper structure surface to realize quantum entanglement

Professor Wang Mu and Professor Peng Ruwen research team of Nanjing University School of Physics Based on the concept of geometric standards they previously proposed, the concept of the geometric standards [Physical Review x 10, 031035 (2020)] constructs a new type of medium supercomprites, and realizes multi -channel multi -channel in quantum entanglement state. Transformation and distribution. The study laid the foundation for the integration of integrated optical quantum networks that meet the needs of multiple user diversified communication. This quantum entanglement distribution scheme is achieved through two medium super -structured surfaces based on the geometric standard phase. Traditional optical meta components such as beams and prisms laid the foundation for miniaturization and integration of optical quantum networks. The innovation of this research is that for the integration of the future optical quantum network, design and prepare a new type of polarizing entanglement system, and the transformation system of volatile entanglement. With distribution. The medium hyper constructor based on the geometric standard phase to realize the multi -channel transformation and distribution diagram of the quantum entanglement state

The latest research results of hand -to -hand multiple resonance materials and round polarized light emitting devices

Most of the construction of hand TADF materials adopts the strategy of micro-disturbance, and uses a traditional-receptor structure. However, this usually leads to a wide range of material launch bands, and it is difficult to achieve solid color launch. Zheng Youxuan team of the School of Chemistry and Chemical Engineering of Nanjing University proposed a spatial position to assist dual -core strategies, while at the same time, it realized the characteristics of narrow spectrum and round polarization launch. The team members prepared multiple resonance TADF (CP-MR-TADF) materials with a shaft-handed structure by connecting the two single-core multi-resonance TADF (MR-TADF) units for special sites. Two cores of two cores of dual-core structures (R/S-DOBN and R/S-DOBNT) with spatial block resistance are relatively independent, showing the characteristics of dual-channel transition. Keep consistent with the single -core structure. At the same time, because the two glowing cores jointly construct a shaft hand center, the hand center is fully involved in the luminous process of the material, so a clear CPL signal is shown in the film. For the first time, the order of round polarization pure blue light was achieved for the first time. It is difficult to obtain the signal of the material in the solution. The team members explained the causes of this special phenomenon through detailed theoretical calculations and experimental verifications, and also provided a new idea for the design of hand -luminous materials.

High -resolution nano -hole accurately distinguish the explanation genetic modification

南京大学化学化工学院黄硕团队构建了一种超高分辨的工程化纳米孔，可以准确的识别所有RNA核苷酸和它们的主要修饰，包括5-甲基胞苷(m5C)， N6 -甲Genosine (M6A), N7 -methylbia (m7g), N1 -methylinosine (M1A), mysicides (i), pseudouriol (ψ), and dihydrous pyrine (D) At the same time, the accuracy of machine learning recognition is as high as 99.6%. Subsequently, the research team applied this method to the apparent genetic modification identification of natural RNA, and realized the direct and quantitative analysis of the decoration nucleotide in the separated RNA digestive products, successfully drawing the modifier of the gastrointestinal cancer logo MiRNA and the yeast TRNA Essence This research method is suitable for a large amount of nucleotide, nucleotide modification and nucleotide derivatives. It provides high -resolution single molecular analysis tools for rapid and quantitative analysis of apparent modifications in natural RNA, and sequencing edge enzyme cutting edge sequencing Objective gene sequencing of nanohole RNA provides important design strategies and research methods.

Use high -resolution MSPA nanohole to distinguish RNA nucleotide and its epigenetic genetic modification

New progress has been made through big data research through big data research

Zhang Shuhan, a doctoral student at the School of Earth Science and Engineering of Nanjing University, used paleontology to make progress in the research on the distribution model of carbon to three stacks of marine life. Modern biological diversity gradients are generally decreased from equator to dual -pole. However, fossil data gives more complicated biological variety gradient mode. Previous research emphasized the important role of energy and climate control, but ecologists and paleontologists have different effects on the impact of historical inheritance on biological diversity gradients. One of the important methods of solving this difference is to establish a long -term latitude distribution mode of continuous biodiversity at a long period of time. This study is based on the discovery data of 30,3770 fossils from the Paleobiology DataBase in Paleobiology DataBase, screening marine vertebrates, and building a lattice gradient mode for 150 million years of weir -woven marine life. The method of type method analyzes the effects of sampling deviation and spatial distribution on the effects of reconstructed latitude diversity gradient. In addition, through the calculation of the variety of biological evolution and biological diversity, the magnitude of the change of weft change has accurately constructed the various gradient patterns of the charcoal to three stacked ice rooms and the greenhouse climate, and diverse of biological biological periods during this period. The reasons for changes in sex distribution mode put forward new understanding.

Carbon to Sanpaji (3.6-20 million years ago) marine vertebrate latitude variety gradient mode (A, original data; B, standardized results) indicated the global biological diversity center to the north and the ancient sector north to the north Movement process (C). 15

In the process of BESIII experiments J/ψ-υπ+π-η ', X (2600) new particles were found

The Beijing spectrometer BESIII experimental group on the Beijing Positive Electronics collision uses the 10 billion J/ψ experimental data that has been collected to see the X (2600) particles for the first time in the process of J/ψ-υ π-π π '. The results of this experiment were cooperated by Professor Jinshan, Professor Jinshan of the School of Physics of Nanjing University, and Huang Yanping Young Researcher and Lou Xin Chou researcher in the Institute of High -Energy Physics of the Chinese Academy of Sciences. This new particle X (2600) observed in the process of BESIII cooperation group observed in the process of J/ψ-υ π+π-η '. The experiment confirmed that its statistics were significantly greater than 20 times the standard deviation, as shown in Figure 1, and measured the measurement and measured To the output of two main decay modes of X (2600) F0 (1500) η 'and x (1540) η' '. This result is to find another new important achievement in the field of new strong sub -state. In the next step, find X (2600) particles in more decay and determine its self -spin, which is essential for understanding the essence of X (2600) particles.

Quality spectrum

Professor Tang Shaochun and Professor Meng Xiangkang won the 23rd China Patent Outstanding Award

Recently, the State Intellectual Property Office issued a decision on the 23rd China Patent Award. As the first patent owner, Nanjing University, the national invention patent "dual -metal/carbon layer composite ball" of Professor Tang Shaochun and Professor Meng Xiangkang's team of Professor Tang Shaochun and Professor Meng Xiangkang at the School of Modern Engineering and Applied Sciences of Nanjing University. (Patent number: ZL201210298558.3, Inventor: Tang Shaochun, Meng Xiangkang, Li Nanting, Gao Wenhua) won the 23rd China Patent Outstanding Award. Nano -composite materials are known as "new materials for the 21st century". The research and development and application of new materials for new materials meet the requirements of international green industry development and the construction of sustainable development and ecological civilization in my country. It is the most advanced green chemical new material. Good choice. The invention patent of this award-winning invention provides a one-step fast preparation method based on dual-metal/carbon layer-shaped compound balls growing in nuclear and limited domain growth, which is completely opposite to the traditional bottom-up path reported internationally. The control of nanoparticle size and digital density can also regulate the distribution position of particles in the three -dimensional space; the product purity is high, has a unique layered structure, fast response rate, high yield; good response controllability, technology applicable technology applicable wide range. The team uses this as a core technology to combine multiple enterprises to conduct industry -university -research cooperation, and has developed new and low energy consumption processes and equipment for large -scale materials. This patent breaks the design of multi -metal/carbon composite material structure and precise regulatory technical barriers, and has promoted technological progress of nano -functional materials.

Reveal the new mechanism of the overall metabolism of mitochondria in mitochondria in mitochondria

As the largest energy metabolism and endocrine organs of the human body, skeletal muscles are essential for the body's metabolic balance. In -depth research on the regulatory mode of skeletal muscle metabolism is expected to provide new theories and new strategies for the prevention and treatment of metabolic diseases. Professor Gan Zhenji's research team of Nanjing University Medical College has revealed a vital role in regulating skeletal muscle mitochondrial functions and body metabolic stability in the mitochondrial pathway of skeletal muscle. The important mode of mitochondrial autophagy regulating muscle-metabolic communication ". Based on this research, the group further explored the first line of defense of skeletal muscle mitochondrial quality control -mitochondrial protein steady -state control on muscle metabolism. Researchers have comprehensively applied systemic methods such as mito-time reporting system, non-folding protein chemicals, high-throughput transcription groups, and gene knockout/genetic operation methods for mito-timer reporting systems, non-folding protein chemical small molecules. This study defines the mitochondria Uprmt, reveals the new physiological function and action mechanism of UPRMT in mammals, and clarifies the long -distance regulating liver and fat metabolism through ATF4 non -dependent mechanism of skeletal muscle mitochondria.

Skeletal muscle mitochondria UprMT through ATF4 non -dependent mechanism long -distance control overall metabolism

Time and space resolution of the transliteration of photovoltaic interfaces

The space -time evolution of the optoelectronics interface is closely related to the fields of energy, catalytic and sensing, and is one of the research hotspots in the fields of physics, chemistry and materials in recent years. The migration, distribution, and relaxation of the carrier are the key to affecting the function of the material. Kang Bin and Xu Jingjuan team of the National Key Laboratory of the School of Chemistry and Chemical Engineering of Nanjing University combine the femlose pump-detection technology and interference scattering micro-surgery It has been developed into the first FEMTO-ISCAT (FEMTO-ISCAT) and successfully obtained the authorization of invention. As a general measurement platform, the instrument realizes super -sensitive and high -throughput observation of load migration, distribution and relaxation dynamics in various materials. Through interference and amplifying effects and space light field modulation, the comparison of transient images has increased by more than two or more compared to the traditional method. The rare scientific phenomenon. Compared with the traditional transient microscope compared to the traditional transient microscope, FEMTO-ISCAT has greatly expanded the scope of application of materials and achieved multi-functional imaging of the current evolution of carriers with extremely high sensitivity and detection flux. Research on the process. Femittond interference scattering imaging principle

Artificial specification field realizes colorless dispersing coupling waveguide can be used for large -scale photon integration

Recently, Professor Li Tao and Academician Zhu Shining in Nanjing University Modern Engineering and Applied Sciences have made important progress in photon integration. The colorless dispersing coupling between the integrated waveguide is achieved to achieve broadband, robust, and high -integrated optical wave -guided coupling and beam performance, and display the 18 -optic integrated network function of the three -level couplet. In the early work, the research team has realized the sub -wavelength self -imaging function (ADV Photon 2, 036001) in the high -density integrated bending silicon waveguide, and the artificially regulating topology interface (Laser Photon. Rev. Rev. 15, 2000584 (2021), demonstrating the possibility of controlling light at the long scale of the sub -waves, as well as the application prospects of integrated photonology. In this work, the researchers carefully studied the source of color scattered between the coupling waveguide, and proposed that a new artificial specification field (AFG) color scattered item can be introduced through regulating waveguide bending. Under the appropriate parameter, the AFG color scatter items can be opposite to the color scattered of the traditional straight waveguide, and fully compensated within a certain wavelength range to achieve zero -color scattered characteristics. At the same time, the distance between the coupling waveguide and the coupling distance can not change significantly, which gives the broadband coupling function of high -density integrated waveguide, that is, light of different frequencies can be coupled to adjacent waveguide (see the schematic diagram). Thanks to this broadband characteristics, its coupling effect is also significantly reduced to the distance sensitivity of waveguide. It has structural robustness and is greatly conducive to large -scale photon integration.

Colorless dislike couple between wave guides