Decisive dosage?He broke the inherent thinking and proposed that he had tailor -made clothes

In 1989, this deafening view appeared on the most authoritative magazine in the field of clinical medical science. The point of view of the view is Zhou Hongzheng, a Chinese scholar.

Earlier, the international medical community was even more popular with the discussion of "weight decision dosage". Zhou Hongzheng's article not only changed people's inherent medication thinking, but also inspired the research on the pharmaceutical community on the differences in drug reaction racial differences. Since then, a new era of medication has been opened.

But many people don't know that Zhou Hongzheng, who has built a lot in the field of pharmacology, has almost embarked on the road of art.

Academician Zhou Hongzheng

On the sun, his direction

Zhou Hongzheng has a master song called "Sunshine Road".

"On the road of sunshine, the banner is flying. Scientific development into a harmonious China, leading the direction ..." The song is confident and won the applause for him. The Conservatory of Music has indeed appeared in his college entrance examination options.

Zhou Hongzheng grew up in a family with a strong artistic atmosphere. His father, Zhou Lei Village, was the principal of the high -level art college of Huazhong, and his aunt was a music teacher. "Home and art seem to have fate." Zhou Hongyi said.

In such an environment, the young Zhou Hongzheng's original ambition was "teaching". What do you teach? He was a little hesitant. As a top student in the class, he can apply for excellent science and engineering institutions; but he is also a good seedling of the Changsha Middle School Student Choir, and it is natural to apply for the Conservatory of Music.

Academician Zhou Hongzheng sang at the party

However, by chance, Zhou Hongzheng was invited to go to the hospital where his classmates work to work. This turn completely changed his thoughts. "I visited the hospital that time, and I saw the sacredness of the doctor's occupation, especially the doctor could help patients reduce pain and deeply infected me."

In 1957, Zhou Hongzheng was admitted to the Medical Department of Wuhan Medical College with excellent results. A few years later, he obeyed and prepared to stay in school as a teacher. Until a notice disrupted the upcoming new life -he was going to the Hengyang Hospital of the Guangzhou Military Region Air Force to be an internal medicine doctor.

Since 1962, he has been in Guangzhou for 7 years. In the past 7 years, he not only grew into a confident and mature internal medicine doctor, but also became the backbone of the army's propaganda team. But how to go further in his professionalism has always been in his heart.

"I am a person who wants to have achieved something, not a person who lives in muddy." For this reason, Zhou Hongzheng chose to transfer to his hometown. Although his wish was to be taught again, because of the university's suspension, Zhou Hongzheng was assigned to a state -owned factory as a doctor, and it was 7 years.

But 7 years and 7 years, Zhou Hongzheng always prepared to embark on his "Sunshine Road". In 1978, his long -awaited opportunity finally appeared.

"People do not have advanced consciousness, and they are always backward."

Taking advantage of the spring breeze of reform and opening up, Zhou Hongxun keenly seized the opportunity of "university resume", and immediately recommended it to Mao Sui, Hunan Medical College, and was transferred to the school's teaching and research room that day.

"People don't have advanced consciousness, and they are always backward." Zhou Hongyi said. He didn't want to "follow others forever", which also made him staring at the problem after starting to study clinical pharmacology. Among them, the most typical question is: "Why is the dose used in foreign patients, and the dose of Chinese patients is small? Is it because of the difference in weight?"

With this question, Zhou Hongzheng put forward a bold assumption. He believed that the main reason for deciding the dosage was not the weight, but the inherent differences in the inherent inherent of the race.

Since then, Zhou Hongzheng stood out from nearly 100 applicants around the world and successfully obtained the Merck Scholarship. With scientific research funds and his own topics, he entered the University of Van Detbit, the university in the United States.

The English that worked hard in the early years finally had the power to use martial arts. He did not understand the experimental instruments and did not operate the computer. Zhou Hongzheng, who was unable to find a research target for the lack of diversification of races, was helped by many friends.

In this way, Zhou Hongzheng's research on Puylol, morphine, and Atto all confirmed the racial differences in the existence of drug metabolism and pharmaceutical effects.

In 1989, at the suggestion of a friend, Zhou Hongzheng contributed to the New England Medical Magazine and was received one week later. After obtaining a major breakthrough, Zhou Hongzheng pursued the direction of research to study the direction of research. If there was no accident, he would stay in the United States to continue research.

But Zhou Hongzheng once again made different choices.

Academician Zhou Hongzheng and students

Nothing to report to the country

At that time, Professor Luo Jiadian, who was the president of Hunan Medical University, issued an invitation to return to the country to teach, and Zhou Hongzheng immediately agreed. In 1991, Zhou Hongzheng returned to his homeland with his family and more than thirty boxes of daily necessities and school supplies.

After returning to China, Zhou Hongzheng put his eyes on ethnic differences. Beginning in 1993, Zhou Hongzheng led graduate students to the western Hunan, Guangxi, and many remote forests in Guangxi and Yunnan to collect blood samples to study hard, but Zhou Hongzheng was among them. "I don't feel hard, because I'm doing what I like to do, this is the greatest pleasure."

With this rigorous and optimistic scientific research spirit, in the following 10 years, Zhou Hongzheng successively confirmed the "drug metabolic enzyme gene dose effect", "drug interaction affected by gene regulation" and "drug reaction race differences Differences "Differences" three laws. At the same time, the claim of "tailoring and taking medicine" was put forward. With the development of individualized therapy research, Zhou Hongzheng led the team to successively establish the first domestic "individualized treatment consulting center" in Xiangya Third Hospital of Central South University and the first "individualized treatment genetic analysis center" in the country. In 2001, he It also led the team to develop the first international "hypertension individualized medication chip" to develop the first internationally disease.

First and again, Zhou Hongzheng was named "Father of Genetic Pharmaceuticals". But he is more willing to be called "the son of genetic pharmacology."

Despite numerous achievements, Zhou Hongzheng still believes that he can do a lot. He said: "How to use new technologies to push genetic pharmacology to a new stage of development is a problem that countries around the world are exploring. In this process, the development of China's genetic pharmaceuticals does not lag behind abroad, and keeps moving forward, walking farther and farther. "

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