"German Applied Chemistry" reports new progress in research in the field of Hua Li's foundation

Recently, Professor Chen Yifeng, a School of Chemistry and Molecular Engineering of East China University of Technology and Ferrina Nobel Scientist Joint Research Center, has achieved new research progress in the field of nickel catalytic radiation. The relevant research results are "Carbonylative Cross-Coupling Reaction of AllyLic Alcohols and Organoalanes with 1 ATM Co Enabled by Nickel Catalysis "was published in" German Applied Chemistry ".

Astone is the basic functional group of organic small molecular compounds. Among the synthesis methods of many ketone compounds, the three -sets of mirroring catalysis catalyzed by the transitional catalysis are one of the most effective methods. Due to the "toxic" effect of CO molecules in the center of metal nickel center, the reaction of high -yield metal nickel catalytic catalytic pyrodiacocladiated puppets started late. In recent years, the reaction of the pillarization of ligands to promote nickel catalysis has gradually attracted people's attention, mainly using organic (pseudo) halide as a parental reagent. At present, the direct cylinder reaction of the more cheaper and easy -to -access alcoholic compounds through nickel catalysis still has huge synthetic problems.

In response to this challenge, Professor Chen Yifeng's research team can effectively activate the nature of the C-O key based on the Nickel-based catalyst. The connection reaction synthesizes a series of β, γ-unsaturated ketone compounds, and the reaction has a wide range of substrate applicability. This is also the first example of a transitional metal catalytic alcohol as a parentic component to participate in the pyrine -based coupling reactions to generate ketone -based compounds. The use of organic aluminum reagents is very important. Its strong hypoxicity and Louis acidicity can effectively activate carbon oxygen bonds, avoid the addition of additional activation reagents, and can also participate in the coupling group as a carbon component. Using the nickel carbon oxygen key to restore the unfavorable characteristics, this response can be compatible with a series of lively hydroxyl groups, such as phenol, alcohol, alkyl alcohol and other functional groups, to achieve a highly chemical selective pyrinated puppet reaction of alcohol.

Doctoral student Wang Chenglong is the first author of the article, and Professor Chen Yifeng is the author of the work. Related research work has been strongly supported and carefully guided by Professor Qu Jingping. The research work has received the Ministry of Materials Biology and Dynamic Chemistry Education's cutting -edge science center, Ferrich and Nobel Prize Scientist Joint Research Center, the National Natural Science Foundation of China, Shanghai "Star Star" plan, Shanghai Natural Science Foundation Project funds such as fund scientific research business fees and support of Chinese post -doctoral science funds.

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