Young or middle age "inflammation", the harm may accompany you for a lifetime

Observe the peers around you. Some people are more likely to get sick, and the physical function is aging faster. Why?

Recently, a study published in the subsidiary of the international stem cell authoritative magazine "Cell" found:

The inflammation stimulus when you are young may endanger your life, especially for a long -lasting impact on the hematopoietic system, and accelerate cell aging.

"Life Times" (search for "LT0385" in WeChat can be followed) to interview experts to tell you how inflammation is buried in health hazards, and teach you to correct inflammation to the body.

Interviewed expert

Ren Jingjing

Wang Yuedan, a professor at the Department of Immunology, Basic Medical College of Peking University

Inflammation damage may accompany the lifetime

What did this study conducted by the German Cancer Research Center and other teams? In simple terms, it can be summarized into three aspects:

Inflammation stimulation will reduce the hematopoietic function

In order to evaluate the impact of repeated inflammatory stimuli, the research team has repeatedly injected stimulators that can cause short -term sterile inflammation.

After the 4 -week recovery period, the researchers found that the number of mature blood cells in the body had not changed significantly; but the "cloning formation ability" and "proliferation potential" of hematopoietic stem cells were significantly reduced.

It should be clear that hematopoietic stem cells are the origin of hematopoietic cells and immune cells. It can not only differentiate into red blood cells, white blood cells, and platelets, but also span systems into cells of various tissues and organs, which have split, proliferation and differentiation functions.

Damage is cumulative and irreversible

In addition, the research team also conducted a mixed bone marrow transfer experiment. After one year of observation and analysis, it was found that:

Compared with the control group mice, the functional hematopoietic stem cells of the inflammatory stimulating group mice are reduced by about 20 times;

And with the increase of the number of stimuli, the ability to make hematopoietic has weakened, which indicates that the damage of inflammation can be accumulated.

Inflammation will accelerate cell aging

At the same time, the research team detected the level of epigenetics of two groups of mice, and found that the epigenetic school age of the stimulating hematopoietic stem cells stimulating the hematopoietic stem cells was greater than its actual biological school age. This shows that inflammation is the driving factor of accelerating aging of hematopoietic stem cells.

In summary, this study tells us that inflammation can cause "accumulated" and "irreversible" function damage to hematopoietic stem cells, and have a long -term inhibitory effect on hematopoietic.

In other words, the inflammation of youth or middle -aged inflammation is likely to continue to exist and affect the hematopoietic system of the elderly.

I was buried in the inflammation and the body was buried early

In the development of some major diseases, inflammation reactions are one of the important links. When local tissue cells are damaged, the body releases inflammatory factors, causing local inflammation.

This is conducive to improving the body's local resistance to the pathogen and the ability to repair tissue cell damage. However, if inflammation cannot be effectively controlled, it may be due to excessive defense damage to health.

In addition to the impact of the hematopoietic function, many diseases seem to be unsatisfactory, but there are often common soil behind them -inflammation.

Activity with cancer

Long -term inflammation state may cause disorders of the immune system function, and the ability to identify and clear tumor cells cause obstacles. For example, gastritis caused by pylori infection of Helicobacter pylori may develop into gastric cancer.

Casting cardiovascular disease

The inflammation caused by immune disorders often invades the inside of the vascular wall, causing damage to the vascular wall, forming plaques in the blood vessels, and even thrombosis, leading to the attack of coronary heart disease.

The seeds of buried diabetes

In the development of diabetes, the inflammatory response will use the oxidation stress mechanism to damage the vascular and tissue endothelial cells, which affects the transfer and absorption of insulin in the tissue and cause insulin resistance.

Injury nervous system

The discharge of inflammation reactions can also produce neurotoxicity and damage neuron cells. For example, the star gel cells and small gel cells in the brain of elderly dementia will release the inflammatory factor in the inflammatory response and exacerbate the degenerative lesions of the neurons.

Raise the chance of obesity

Defendum tissue can not only store energy, but also contain macrophages. When the fat stacked fatty cytokine is excessive, it will cause chronic inflammation of the whole body, and the fat tissue macrophage infiltration will exacerbate this chronic low inflammation state.

Because of this, obesity is regarded as a disease and is often accompanied by a variety of complications.

Increase the risk of depression

During the onset of depression, inflammatory cytokine release and inflammatory response were active. Not only does the inflammatory factors increase in depression, but also enhanced inflammatory reactions.

Intitis control from 5 things

As long as the factors that can cause tissue and cell damage can cause inflammation, in general, it can be divided into endogenous and exogenous factors.

Endogenous factors: including DNA damage, abnormal telometer function, oxidation stress, etc.;

External factors: Infection, external environment and poisonous stimuli, bad eating habits, etc.

Endogenous factors are difficult to change, but we can avoid or control inflammation by reducing the impact of exogenous factors. The most important of which is to improve the living environment and lifestyle.

Stay away from pollution environment

Hidden factor that can cause inflammation everywhere in life, such as viruses, bacteria, fungi, and parasites, chemical factors such as strong acids, strong alkali and formaldehyde, and improper use of drugs and other biological agents.

Try to avoid contact with harmful substances, clean up at home, ensure that the indoor environment is clean and tidy, do not use medicine, try not to use products such as pesticides, hair dyes, etc. that may contain harmful substances. Good mood and regular work

Continuous psychological pressure may destroy the body's ability to regulate inflammatory activity; day and night disorders caused by staying up late, it will also increase the risk of a variety of inflammatory diseases.

To maintain a positive and healthy attitude towards life, sleep enough for 7 to 8 hours a day. You must learn to regulate your emotions when you encounter unsuccessful things. If necessary, you should ask a psychologist for help.

Develop exercise habits

When muscle contraction, it can secrete some cytokine and a smaller molecular weight muscle protein. These substances enter the blood to reduce the inflammatory response of the whole body to a certain extent.

To develop good exercise habits, not only to do aerobic exercise, but also pay attention to enhancing muscle strength. It is recommended that people who allow physical conditions to do some weight exercises appropriately.

eat less junk food

Unhealthy eating habits, such as eating high -salt, high oil, and high -calorie foods often change the intestinal flora, increase intestinal permeability, and easily cause chronic inflammation.

For example, some cakes in some pastries, the ultimate products of glycated in barbecue, and a large amount of meat, especially red meat, etc., will increase the inflammatory response.

Eat some "anti -inflammatory food"

Dr. Andrew Well, a professor of medical at the University of Arizona, has a well -known "anti -inflammatory food pyramid" theory. He pointed out-

The anti -inflammatory effect of fruits and vegetables is the best. At least 4 to 5 dishes per day, about 80 grams each;

Rough grains, pasta, beans are secondary, and they must be eaten every day;

Organic rapeseed oil, nuts and other healthy fats are third;

Fish and seafood can take 2 to 6 copies per week (about 113 grams).

In addition, mushrooms, eggs, yogurt, ginger, garlic, tea, walnuts, coffee, etc. all have anti -inflammatory effects.

Changing lifestyle can improve the level of immunity and have a good effect on controlling and alleviating chronic inflammation. However, if you have severe acute inflammation or disease caused by inflammation, it is difficult to control the lifestyle alone. You should be treated in accordance with the doctor's advice to avoid various complications caused by inflammation.

Editor in this issue: Zheng Ronghua

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