New antibodies can neutralize the new crown virus known variant, which will give birth to a new type of vaccine

American scientists have developed a new extensive neutralized antibody. The preclinical test results show that it can neutralize the newly known variable strains, including all Omircong variants, which may increase people's resistance to the future variant of the new crown virus virus. The ability to give birth to a new type of new crown vaccine. Related studies were published in the latest issue of Science · Estenate.

In order to develop this antibody, Dr. Frederick Aldon, one of the research leaders, and Boston Children's Hospital, used a improved version of the humanized mouse model. They first inserted the two human gene fragments into the mouse body, pushing their B cells to quickly produce a variety of humanized antibodies, and then exposed the mice to the new crown virus spines (the main target of antibodies and existing vaccines) Essence In response, the mice edited by genes produced 9 humanized antibody spectrum combined with spiny protein.

Subsequently, Alde team cooperated with the University of Duke University to detect the effectiveness of these antibodies. The results show that there are 3 spectrum antibodies in the nine spectrums that can neutralize the primitive strains of the new coronary virus, especially the SP1-77 antibodies and their spectrum members show very extensive activity, neutralizing the new crown virus Alpha, Beta, gamma , Delta and Omikon, all strains.

What makes SP1-77 antibodies have such a wide range of neutralization? Structure studies have shown that SP1-77 is very different from the working principle of current antibodies. Researchers explained that many antibodies are available to prevent the combination of new coronary viruses 2 (ACE2) receptor in combination with spiny protein receptor (RBD) in a specific location (RBD). The SP1-77 antibody is also combined with RBD, but the method is completely different. It will not prevent the combination of virus and ACE2 receptor. However, SP1-77 can prevent the fusion of virus outer membranes and target cell membranes, which hinders the last necessary step of virus infection.

"We hope that this humanized antibody is as effective as the new coronal virus in the neutralization of the patient's body as proven in clinical evaluation." Researchers said that SP1-77 has not yet been specified in any new crown virus variant so far The site of the medium mutation is combined with the spiny protein to neutralize all current variants through a new mechanism, which provides valuable information for designing a new type of new crown vaccine.

Source: Science and Technology Daily

- END -