Is it expected to solve the problem of organs?American scientists successfully transplanted two genetically modified pigs to the human body, and no rejection occurred in three days

On July 12, researchers at the Landney Medical Center of New York University announced that they had successfully transplanted the pig heart edited by genes to two patients with brain death.

Researchers said at the press conference that the medical center conducted a transplant surgery in June and July, and conducted a three -day observation test on the recipient. During the period, no rejection occurred, and the heart function was normal. This means that it is closer to the use of animal organs to solve the shortage of supply organs.

↑ Data diagram. On January 7, the University of Maryland's surgeon transplanted the heart of the pig into the patient David Bennett's body

According to reports, the shortage of organs of supply organs is one of the biggest issues that restrict organs transplantation. More than 100,000 people in the United States are transplanted in the waiter. Researchers have been committed to studying heterogeneous transplants, hoping to help meet the needs of organ transplantation. Among them, pigs have always been considered a potential source of transplant organs, because in terms of anatomy, pigs have many similar aspects to humans.

It is understood that the organs on the pigs have been widely used. For example, the heart valve of pigs is routinely transplanted into the human body, and diabetic patients receive pig pancreatic cells, and the skin of pigs transplanted with burns.

In September 2021, the research team of the Landney Medical Center of New York University and the University of Alabama transplanted the genetically modified pork kidney into patients with genetically modified pork kidneys.

In January of this year, David Bentet, a 57 -year -old patient, received the first transplantation of the world's first transgenic pig heart. According to reports, the genome of the somatoscopy has 10 gene modifications. After surgery, the situation of Bennett recovered well, and no rejection was generated within a few weeks. In March, Bernett died at the Medical Center of the University of Maryland. The doctor found a pork cytoplasm virus in his blood, and said that it might be that the pathogen caused his death.

In June and July of this year, Lawrence Kelly and Alva Kapano accepted the transplantation of genetically modified pigs and observed three days. During the period, the two patients had normal heart function and did not find signs of pork giant cell virus infection. Nades Momo Sami, Director of Heart Transplantation Surgery at the University of New York, said more research is needed to determine the long -term situation of the recipient.

At present, Researchers in New York University believe that studying heterogeneous transplantation is safer to studying heterogeneous transplants and can conduct biopsy more frequently to obtain richer information.

Researchers said that the "procurement, transportation, transplantation and immunosuction" during the genetic transplantation surgery of genetically modified pork is the same as the typical human heart transplant surgery. Mo Sami said that this is to verify whether the genetically organs can work normally with the addition of an additional help without equipment or drugs.

Mo Sami believes that although this study represents a progress, it takes a long time from experimental research to clinical long -term applications. "There are still many questions to answer."

Red Star reporter Xu Cai intern Yin Keran

Edit Zhang Xun

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