Recycling of brain regeneration: bring new hope to the regeneration of the brain

Recently, Professor Fei Jifeng of Guangdong Provincial People's Hospital and many research institutions at home and abroad have published the author's joint communications authors on the top international journal "Science" ("Science") entitled "Utilizing the use of time and space transcription group technology to analyze the brain regeneration. The original papers of the key stem cell subcontay ". The study reveals the important mechanism of starting the brain regeneration. Through further in -depth research, it is expected to solve the mysteries of the human brain, and provide effective Clinical plan.

After being damaged, the brain still lacks effective treatment methods in clinical practice. How to find the way to regenerate the damage brain? Is currently known champion of the four -foot vertebrate regeneration. Its brain, spinal cord, limbs, and various organs can be almost perfectly regenerated after receiving damage. Professor Fei Jifeng said that using the characteristics of the damaged brain to use 蝾螈 to be perfectly repairing the damaged brain, the research team found the "seed" cells that started the brain regeneration and repair, and drawn the blueprint for the brain regeneration process.

This study first discovered the key "seed" cells that mediated the regeneration after the brain injury --- a category is different from the sub-group that is very similar to the state of the brain adult neurotransomy, but it is very similar to the early stem cell state. Through comparative brain regeneration and the stem cell differentiation path during development, and the corresponding molecular regulation network, it is found that the regeneration process is actually a reproduction of brain development. In the process of regeneration of the brain, it can realize the return of the brain nerve stem cells and further to repair the brain of regenerating damage through the cells and molecular mechanisms similar to the brain development of the brain during the embryo period.

Most of the various organs of the human body are formed in the process of developing in the early days of embryo. With age, accidents or diseases can lead to organ damage and failure, which is a major factor that endangers human health. The regeneration and repair ability of most organs, including the brain, is very weak. Can it be able to start repairing the in situ of the damaged organs through the means of manual intervention?

Based on the current research results, the research goal of the next step is to achieve brain regeneration in the body of mammals including humans. It involves the activation of the "seed" cells and the introduction of key factor, thereby opening the switch of the human brain regeneration. The successful implementation of the final research plan will be expected to formulate a new treatment method to improve the clinical rehabilitation of patients with brain diseases-that is, to achieve regeneration of human brain regeneration. At the same time, the research work of the multi -organization and organ regeneration mechanism currently carried out by the research team is also expected to learn from the formulation of other human organ and organ regeneration strategies.

Professor Fei Jifeng and Mexico's blunt mouth (a laboratory's commonly used crickets) have been fate for more than 20 years. During studying abroad, he studied the research and genetic research and genetic research from Max Plastic cells in Germany. Professor Wieland Huttner and Professor Elly Tanaka, director of the German Dresden Regenerative Treatment Center. After returning to China, Fei Jifeng established a unique experimental platform in the world's leading in the world with Mexican blunt mouth as a model to study tissue organs. In recent years, it has cooperated with many research teams such as Professor Tanaka to analyze the Mexican blunt cheat genome and is one of the largest animal genomes currently sequensed by humans. At present, the laboratory mainly uses a series of technical systems constructed to combine the regeneration advantage of the 蝾螈 central nervous system to focus on the regeneration and restoration mechanism of the central nervous system to closely integrate research results with clinical needs. Improve effective drugs for human brain regeneration. (Wu Chunyan, all media reporter of Guangming Daily)

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