"Autumn Water Posten" to prevent gout: You must know these 3 points!

For medical professionals for reading reference

Evidence -based medicine, reasonable medication

Vetestity Posort is a drug extracted from the autumn water fairy. The multi-effects of alkaloids are related to the combination of it and microtubules.

Clinically, it is mainly used to treat acute seizures of gouty arthritis to prevent the acute attack of recurrent gout arthritis [3]. In recent years, studies have shown that the mechanism of collateral intervention in autumn water may stem from its impact on inflammatory symbols and platelet activity, and it is also used for the treatment of coronary heart disease [4].

Because the therapeutic dose of collusted in autumn water is close to the poisoning dosage, long -term use of autumn water pylopia is prone to poisoning, and it should be alert to its safety in clinical use.

Use this product for a long time,

It can cause neuromuscular toxic reactions

According to reports, long -term use of autumn pyrophexine for the treatment dose can cause neurotoxicity and horizontal muscle to dissolve, especially when combined with other drugs known to cause this effect. The risk of patients with kidney dysfunction (even patients with normal renal and liver function) will increase. Once autumn water porttic treatment is stopped, symptoms usually fade within a week to several months [5].

At the same time, it is included in Atorvastatin, Simvastatin, Putacine, Flobatin, Louvarin, Jifei Baziz, non -Nobeltite, non -Nobelin acid or benzabet (itself is related to myocardial toxicity) Or pyrumin and other joint use may exacerbate the development of muscle disease [6-7].

Be wary of blood evil liquid

According to reports, the use of autumn water pyrumine, which is treated with dosage, can cause bone marrow suppression, leukocyte reduction, granulocytocytosis, platelet reduction, whole blood cell reduction, and regenerative disorder anemia.

Liver and kidney dysfunction is disabled

Patients with liver and kidney dysfunction should not take autumn posecy capsules and P-glycoprotein and CYP3A4 inhibitors at the same time. In patients with liver and kidney insufficiency, the combination of these dual inhibitors and autumn water pyrosol can lead to life -threatening autumn poison. Patients with liver and kidney dysfunction should not take autumn water portic capsules [5,7].

references:

[1]Martínez GJ,Celermajer DS,Patel S.The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation[J].Atherosclerosis,2018,269:262-271.DOI:10.1016/j.atherosclerosis.2017.12 .027.

[2]Shah B,Pillinger M,Zhong H,et al.Effects of acute colchicine administration prior to percutaneous coronary intervention:COLCHICINE-PCI randomized trial[J].Circ Cardiovasc Interv,2020,13(4):e008717.DOI: 10.1161/Circinterventions.119.008717.

[3] Drug Information: Qiu Shui Shinhide Tablets, Guangdong Pydi Pharmaceutical Co., Ltd., State Pharmaceutical Quanda H20113208; 2020/12/01.

[4] Zhao Ping, Li Mengmei. New progress applied in the rigid heart disease in autumn water. [J]. China Cardiovascular Magazine, 2021,26 (6): 4. 4.

[5] Product Information: Colchicine Capsule, Hikma Pharmaceuticals USA Inc., Updated June 16,2020.

[6] Product Information: Colchicine Tablet, AMNEAA PHARMACEUTICALS LLC, Updated January 14,2021.

[7] Product Information: Gloperba-Colchicine Solution, Romeg Therapeutics, LLC, Updated February 5,2019.

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Source: Clinical Pharmacy Channel in the medical community

School pair: Zang Hengjia

Responsible editor: Wan Shunshun

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