Freshly baked!Fudan August Scientific Research Achievement@You see | Scientific Research Express

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Fudan University Scientific Research Team

Recently have achieved several results and breakthroughs

Xiaobian compiled some scientific research results in August 2022

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Field of chemical materials

1. Peng Huisheng at the Department of Polymer Science won 2022 Falling Walls Science Breakthrough Award

On August 16th, Falling Walls Foundation in Germany announced on the official website the 2022 Science Breakthrough Award. Professor Peng Huisheng at the Department of Polymer Science at Fudan University obtained this item because of the "Fiber Polymer Lithium-In Batteries"). The award, the awards committee believes that this work "overthrow the wall that restricts flexible fiber batteries (" Breaks The Wall to Flexible Fiber Batteries ". The relationship has laid the theoretical foundation for the development of fiber lithium -ion batteries. The fiber lithium -ion battery constructed under this theoretical guidance shows excellent and stable electrochemical properties and can meet the actual application requirements.

News link: https://news.fudan.edu.cn/2022/0817/c40a132174/page.htm

2. Ding Jiandong's research team in the Department of Polymer Science has made new progress in selectively induced cell orientation and migration of gradient biomass

Recently, the Ding Jiandong research team of the Department of Polymer Science was based on Block Copolymer Micelle Nanolithogram (BCMN), which successfully prepared the golden matrix of the gradient change of nano -distance gradient. The difference in response differences between endothelial cells and smooth muscle cells on gradient changes, which provides new ideas for future cell screening and the surface modification of cellular selective materials that promote wound healing. The above research results are published in "ACS AMI"

News link: https://mp.weixin.qq.com/s/voyp6fjcxp1yz61ue7goda

3. Chen Guosong/Jiangming Research Group J. AM. Chem. SOC. Summary: The artificial accurate assemblies of protein and sugar are potential application prospects in the field of biomaterials

On August 31, Chen Guosong/Jiangming's research group in the chemical magazine J. AM. Chem. SOC. (Precise Assembly of Proteins and Carbohydrates for Next-Generation Biomaterials). This article summarizes the accurate self -assembly methods and design strategies currently used in protein and sugar. It describes the artificial accurate archeology of protein and sugar in the potential and attractive application prospects of the biomass material field, and looks forward to the future of the field of the field of the field Facing challenges and opportunities.

News link: https://mp.weixin.qq.com/s/kt6zikjopwt-kfb3azaenq

4. Professor Tu Tao of the Department of Chemistry reported the use of trigly pyrimidine zinc compounds to instantaneous and high -resolution visualization identification of submarine fingerprints

The research team of Professor Tu Tao of the Department of Chemistry has studied the possible mechanism of the probe Zn (TPY-NME2) submarine fingerprint recognition. Wait, a possible identification mechanism is proposed. This work provides a new method for the visual identification of submarine fingerprints in different scenarios. The relevant research results are published in the international first-class academic journal " "Adv. Mater." And were selected as inner cover articles.

News link: https://chemistry.fudan.edu.cn/f4/57/c21871a455767/page.htmm

Information field

1. Zhou Peng/Bao Wenzhong team successfully developed a new principle machine visual enhancement chip

Recently, the team of Zhou Peng/Bao Wenzhong in the Microelectronics Institute successfully prepared a large -scale machine visual enhancement chip with a wafer -grade two -dimensional atomic crystal molybdenum. On August 3, the work progress was published in the international journal "Scientific Frontier" (A 619-Pixel Machine Vision Enhancement Chip Based on Two Dimensional Semiconductors "based on the work progress. Advances). In this work, the research team first successfully grown high -quality and uniform two -inch two -inch materials (MOS2) wafers, and developed an integrated circuit manufacturing process for two -dimensional integrated circuits. News link: https://news.fudan.edu.cn/2022/0804/c5A132107/page.htm

2. The paper published by the System and Software Safety Laboratory of Computer Science and Technology has won the Outstanding Papers Award

Recently, the paper led by Professor Yang Yan, a School of Computer Science and Technology, the School of Computer Science and Technology, Fudan University, published by the Software Security Laboratory "Identity Confusion in WebView-Based Mobile App-in-APP ECOSYSTEMS". Distinguished Paper Awards. The paper focuses on the ecological security of mobile apps, revealing a number of security threats facing a number of mainstream software such as WeChat, Alipay, Douyin, and today, helping avoid the information security risks of billions of users.

News link: https://news.fudan.edu.cn/2022/0822/c5A132207/page.htm

3. The important progress of the Xiao Limin research group of the School of Information Science and Engineering obtained multi -core optical fiber devices

Recently, Laser Focus World, the authoritative media magazine of the optoelectronics industry, reported the breakthroughs of the Department of Optical and Engineering of the School of Optical Science and Engineering of the School of Information Science and Engineering in the Department of Optical Science and Engineering, and highly evaluated "it is expected to accelerate the promotion of data communication networks The development of the cooperation is Professor Xu Lei, Professor Liu Liying, Professor Zheng Jiancheng, Hong Kong University, and Professor Chen Wei of Shanghai University. The above research results are published in Journal of Lightwave Technology in the title "

Earth Sciences

1. Coordinated with the Department of Atmospheric and Marine Sciences, China Meteorological Administration, Scientific Research Institute, and Hong Kong Observatory to carry out the three -dimensional encryption target observation and assimilation forecast test of typhoon "Mulan"

The atmosphere and the Marine Science Department coordinated the China Meteorological Administration, Scientific Research Institute, and the Hong Kong Observatory. From August 8th to 10th, the typhoon four -B satellite high spectrum detector and Hong Kong airborne device coordinated typhoon Target observation test. In this experiment, the original method provided by colleges and scientific research institutes determines the target observation sensitive area. The meteorological business department provides satellite and aircraft observation technology, using my country's own business forecast mode and four -dimensional change data assimilation system to carry out typhoon real -time forecast. Carry out an effective practice of precisely forecast the entire chain of extreme weather and climate events.

News link: https://news.fudan.edu.cn/2022/0815/c40a132165/page.htm

2. The Department of Environmental Science and Engineering Tang Happiness Research revealed the control efficiency of environmental catalysis new machines to improve the discharge of air pollutants

Recently, Professor Tang Xingfu's research team of the Department of Environmental Science and Engineering proposed a new mechanism of environmental catalysis, namely the electronic ionization domain mechanism, and the scientific basis for the concept of electronic ionization mechanism to develop high -efficiency environmental catalysts, which is conducive to improving air pollution Control efficiency of object emissions. Related research results are published in the journal Cell Press CELL Publishing House CHEM Journal in the Cell Press.

News link: https://envalonment.fudan.edu.cn/f1/4e/c26494990/page.htmm

Life Medicine

1. Professor Shi Leming team of the Human Pathum Group Research Institute and the Chinese family group No. 1 Standard substance developed by the Chinese Institute of Metrology Sciences and developed the standard material for formal approval

Recently, Professor Shi Leming team of the Human Pathum Group Research Institute and the China Institute of Metrology Scientific Research Institute team No. 1 (compatriotic twin family) human -originated B lymphocyte whole genome DNA sequence standard substance, China Home Department No. 1 (same egg department 1 (same egg Twin families) Eight national first -level standard substances including the full transcription group of the B lymphocyte Department of the B lymphocyte Department were officially approved and released. News link: https://news.fudan.edu.cn/2022/0824/c5A132219/page.htm

2. The team of Dong Aiwu, Gan Jianhua and Huang Jianxun of the School of Life Sciences revealed the molecular mechanism of different MyB and BHLH transcription factor to select a partner for forming a complex

On August 22, the three laboratories of Dong Aiwu, Gan Jianhua, and Huang Jianxun of the School of Life Sciences published a research paper entitled "Structural Insights Intural Insights INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTS INSIGHTO The study revealed the molecular basis for different MyB and BHLH transcription factor to select partners to form a complex. At the same time, the two types of MyB-BHLH binding models are independent in plants.

News link: https://life.fudan.edu.cn/f3/ca/c281455626/page.htm

3. Wang Yongming research team of the School of Life Sciences developed a CRISPR/CAS9 tool that identifies N4C PAM

On August 12, Wang Yongming's research group published on Elife published a research paper entitled "Closly Related Type II-C Cas9 Orthologs Recognize Diverse Pams". The 25 CAS9 PAM has been identified, and for the first time, the Type II-CCAS9 recognizes the diversity of PAM with a high degree of protein. The study helps the development of new CAS9 tools.

News link: https://life.fudan.edu.cn/f2/23/c28140a455203/page.htmm

4. Huang Qiang research team of the School of Life Sciences published a new method of designing a ribinic acid suitable ligand

Recently, the authoritative academic journal "Biosensors & BIOELECTRONICS" (Biosensors & BioECtronics) in the field of biosensor has published a research paper from Professor Huang Qiang, a key laboratory of the National Key Laboratory of Genetics Engineering: DE Novo Design of Dna Aptamers that target Okadaic Acid (OA) by Docking-then-Assembling of Single Nucleotides. This paper develops a new method of designing a new method from the beginning-Docking-then-Assembling of Single Nucleotides method, and uses this method to design Okadaic Acid (Okadaic Acid OA )'s high -affinity and high -specific DNA adaptation has achieved important results in the design of nucleic acid adaptation.

News link: https://life.fudan.edu.cn/f0/fc/c281404908/page.htm

5. The cooperation of Wang Hongyan team and Wang Chen's team of Wang Hongyan and the School of Life Sciences in the Affiliated Obstetrics and Gynecology Hospital revealed a new mechanism for KCTD7 mutations in neuronal fat brown deposition

8月3日，附属妇产科医院王红艳教授团队和生命科学学院王陈继副研究员团队合作在Science Advances在线发表了题为“KCTD7 mutations impair the trafficking of lysosomalenzymes through CLN5 accumulation to cause neuronalceroid lipofuscinoses”的研究paper. The study found that the KCTD7 loss caused the CLN5 protein abnormality to accumulate in the internal quality network, interfered with sorting and transfer of enzyme hydrolyzed enzymes, which led to the occurrence of enzyme -soluble dysfunction and disease.

News link: https://life.fudan.edu.cn/f0/f9/c281404905/page.htm

6. Professor Shao Chunlin's team research found that SOCS2 has induced SLC7A11 generalization and degradation and activation of iron death by inducing SLC7A11

8月23日，放射医学研究所邵春林教授团队在Cell Death and Differentiation上在线发表题为“SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma”的研究论文，揭示细胞因子信号抑制因子2（suppressor Of Cytokine Signaling 2, SOCS2) is a potential radiation sensitivity target for liver cancer. Excessive expression of SOCS2 can promote the key protein of iron death SLC7A11. This study provides new ideas for the formulation of individual chemotherapy schemes for liver cancer. News link: https://news.fudan.edu.cn/2022/0823/c5A132211/page.htm

7. The Yufa Star Research Group of the Institute of Biomedicine Research Reporting Hippo Pass Cell Cell Surface Regulatory Components and Tumor Objective Treatment Strategy

8月30日，生物医学研究院余发星课题组在Cell Reports杂志以长文形式发表了题为“Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers”的研究paper. The study discovered the new regulatory element Kirrel1 of the Hippo signaling pathway.

News link: https://ibs.fudan.edu.cn/f3/96/c35420A455574/page.htm

8. Gu Hongzhou research team of the Institute of Biomedical Research reports on the controllable self -assembly of the two lips DNA molecules

8月30日，生物医学研究院顾宏周团队在Journal of the American Chemical Society期刊上发表题为“Programmable Assembly of Amphiphilic DNA through Controlled Cholesterol Stacking”的工作，通过深入研究带有胆固醇修饰的DNA组装体的聚集The behavior found that cholesterol at the dual-chain DNA flat end tends to induce a significant tetraphoruida to induce "cholesterol-DNA", not a polyetrack that was commonly considered to be previously considered. Further studies have shown that the tetris quadrilateral stack of the flat end has nothing to do with the shape of the DNA assembly, and the behavior of the four gathering depends on the flat end of the DNA.

News link: https://ibs.fudan.edu.cn/f6/93/c35420A456339/page.htm

9. The latest research results of the Ma Yanlei team of the Affiliated Cancer Hospital revealed the symbol of intestinal cancer intestinal flora, metabolites and bacterial enzymes

A new study led by Professor Professor of Professor 2 Kama Yanlei in the Cancer Hospital of Affiliated Cancer Hospital. For the first time, it revealed that the young intestinal cancer (early hair bowel cancer) and the age of the age of the onset of the age of the onset of the onset of the onset were less than 50 years old. Cancer), there are significant differences in the transformation of intestinal bacteria, metabolic spectrum, bacterial enzyme gene spectrum reform, etc., and based on the "bacterial-metabolic-bacterial enzyme gene combination" logo development diagnostic model. Early screening and precise testing of high -risk population and patients in young bowel cancer further promote the transformation and application of clinical first -line diagnostic strategies in clinical clinical lines. In order to understand the pathogenesis of intestinal cancer in the intestinal cancer, it provided a new perspective and direction for exploring early screening and early diagnosis of intestinal cancer suitable for young people. Related research results have recently been published online in the famous international journal Gut magazine in the world -renowned gastrointestinal field.

News link: https://news.fudan.edu.cn/2022/0815/c5A132166/page.htm

Cross -scientific field

1. The research progress of the calculation method of the Chen Shiyou team of the Chen Shiyou Institute of Microelectronics in the semiconductor in the semiconductor

On August 22, the Chen Shiyou Research Group of Microelectronics Institute, Professor Chu Weibin of the Institute of Computing Material Science, Academician Gong Xingao, Professor Wei Suhuai, Beijing Computing Science Research Center, Professor Zhao Jin, Chinese University of Science and Technology, Professor Wu Yuning of East China Normal University, Empire Institute of Technology Professor Aron Walsh collaborated on the research progress of the African balance carrier life calculation method in the semiconductor. In Semiconductors From Non-Adiabature Molecular Dynamics Simulations ") was published in the journal" Nature Computation ". News link: https://news.fudan.edu.cn/2022/0825/c40a13227/page.htm

2. Professor Deng Chunhui team of Chemistry Department and Professor Shen Xizhong in Zhongshan Hospital affiliated to the Department of Chemistry Research on the Study -based Gastrointestinal Diagnostic New Technology Based on Nano -Materials Assist the External Cancer Spectrum

Recently, the team of Professor Deng Chunhui of the Department of Chemistry and the member of the team member of Professor Shen Xizhong, a subsidiary of Zhongshan Hospital, reported that the integrated and extracted exotic metabolism characteristics were integrated and extracted for early gastric cancer testing. This article is designed to synthesize the adaptive multi-state carbon material, which can also be used as an excellent substrate that is efficiently captured by an external body and the laser rescue/ionization mass spectrum (LDI-MS). Sports and extract its metabolic characteristics to achieve precise early diagnosis and development monitoring of gastric cancer. Related research results were published on ACS NANO.

News link: https://chemistry.fudan.edu.cn/f7/02/c21871a456450/page.htmm

3. Intelligent complex system laboratory in Yu Guo team revealed the computing mechanism of the cortical layer multi -sensing information integration

On August 20th, the basic theory and key technology laboratory of the intelligent and complex system, Professor Yu Guo, and the research group of Researcher Gu Yong, a researcher group of East China Normal University, and the Institute of Nervous Institute. “Unveiling Dynamic System Strategies for Multisensory Processing: From Neuronal Fixed-Criterion Integration to Population Bayesian Inference”的研究论文，该研究为揭示高等动物多感觉脑区进行多模态信息整合计算和认知推断策略方向提供了基础The biological physical theoretical mechanism has an important inspiration for the integration calculation of multi -modal information inspirational artificial intelligence models inspired by brain.

News link: https://mp.weixin.qq.com/s/etozx8mwlehrkyopst- IPG

Source: Institute of Science and Technology Research

Payment: School Rong Media Center

Responsible editor: Zhang Peilin

Edit: Xu Yuan

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